A versatile click chemistry-based approach for functionalizing biomaterials of diverse nature with bioactive peptides

نویسندگان

چکیده

A versatile and straightforward strategy to functionalize biomaterials is described. This click chemistry-based methodology was successfully used polylactic acid, gold titanium surfaces.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Novel Approach for Anchoring Bioactive Peptides to Bone Regenerative Biomaterials

Figure 1. `More E7 peptide is bound to solid HA disks following 21 days of implantation Novel Approach for Anchoring Bioactive Peptides to Bone Regenerative Biomaterials Bonnie K. Culpepper and Susan L. Bellis 1,2 1 Biomedical Engineering University of Alabama at Birmingham 2 Physiology and Biophysics University of Alabama at Birmingham Statement of Purpose: Treatment options for filling bone v...

متن کامل

A versatile "click" chemistry precursor of functional polystyrene nanoparticles.

Functional nanoparticles (NPs) are becoming important building blocks in the emerging fi elds of nanomedicine, nanolithography and nanoelectronics, among others. [ 1 ] Several unexpected nanoscale effects have been discovered for these new materials in recent years. [ 2–4 ] Useful synthetic routes to single-molecule polymeric NPs in the 2–15 nm size range with well-defi ned arrangement of funct...

متن کامل

Click Chemistry: Diverse Chemical Function from a Few Good Reactions.

Examination of nature's favorite molecules reveals a striking preference for making carbon-heteroatom bonds over carbon-carbon bonds-surely no surprise given that carbon dioxide is nature's starting material and that most reactions are performed in water. Nucleic acids, proteins, and polysaccharides are condensation polymers of small subunits stitched together by carbon-heteroatom bonds. Even t...

متن کامل

Versatile click alginate hydrogels crosslinked via tetrazine-norbornene chemistry.

Alginate hydrogels are well-characterized, biologically inert materials that are used in many biomedical applications for the delivery of drugs, proteins, and cells. Unfortunately, canonical covalently crosslinked alginate hydrogels are formed using chemical strategies that can be biologically harmful due to their lack of chemoselectivity. In this work we introduce tetrazine and norbornene grou...

متن کامل

A multifunctional bioconjugate module for versatile photoaffinity labeling and click chemistry of RNA

A multifunctional reagent based on a coumarin scaffold was developed for derivatization of naive RNA. The alkylating agent N3BC [7-azido-4-(bromomethyl)coumarin], obtained by Pechmann condensation, is selective for uridine. N3BC and its RNA conjugates are pre-fluorophores which permits controlled modular and stepwise RNA derivatization. The success of RNA alkylation by N3BC can be monitored by ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Chemical Communications

سال: 2021

ISSN: ['1359-7345', '1364-548X']

DOI: https://doi.org/10.1039/d0cc07463b